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Faculty Member
Postdoc
Ling, Chen
Positions
- Research Assistant Professor, Pediatric Cellular and Molecular Therapy , Pediatrics 2007 -
Affiliation
Publications
selected publications
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letter
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academic article
- The use of miR122 and its target sequence in adeno-associated virus-mediated trichosanthin gene therapy. Journal of Integrative Medicine (Shanghai). 2021
- Development of a rabies virus-based retrograde tracer with high trans-monosynaptic efficiency by reshuffling glycoprotein. Molecular Brain. 2021
- Mild iron overload induces TRIP12-mediated degradation of YY1 to trigger hepatic inflammation. Free Radical Biology and Medicine. 187-197. 2020
- Development of a Clinical Candidate AAV3 Vector for Gene Therapy of Hemophilia B. Human Gene Therapy. 2020
- Site-Directed Mutagenesis Improves the Transduction Efficiency of Capsid Library-Derived Recombinant AAV Vectors. Molecular Therapy-Methods & Clinical Development. 545-555. 2020
- Hepatocyte nuclear factor 4α negatively regulates connective tissue growth factor during liver regeneration. The FASEB's Journal. 2020
- Cellulose-based injectable hydrogel composite for pH-responsive and controllable drug delivery. Carbohydrate polymers (Online). 2019
- Gene manipulation in liver ductal organoids by optimized recombinant adeno-associated virus vectors. Journal of Biological Chemistry. 2019
- TLR9-Activating CpG-B ODN but Not TLR7 Agonists Triggers Antibody Formation to Factor IX in Muscle Gene Transfer. Human Gene Therapy Methods. 2019
- Antifungal proteins with antiproliferative activity on cancer cells and HIV-1 enzyme inhibitory activity from medicinal plants and medicinal fungi.. Current protein & peptide science. 2018
- Chinese medicine protein and peptide in gene and cell therapy.. Current protein & peptide science. 2018
- Clinical use of toxic proteins and peptides from Tian Hua Fen and scorpion venom.. Current protein & peptide science. 2018
- The Hepatocyte- Specific Hnf4 Alpha/Mir-122 Pathway Contributes to Iron Overload-Mediated Hepatic Inflammation. Blood. 130:1041-1051. 2017
- High-Efficiency Transduction of Primary Human Hematopoietic Stem/Progenitor Cells By Aav6 Vectors: Strategies for Overcoming Donor-Variation and Implications in Genome Editing. Scientific Reports. 6. 2016
- Development of Optimized AAV Serotype Vectors for High-Efficiency Transduction at Further Reduced Doses. Human Gene Therapy Methods. 27:143-149. 2016
- Mtorc1 Is Necessary But Mtorc2 and Gsk3 Beta Are Inhibitory for Akt3-Induced Axon Regeneration in the Central Nervous System 2016
- Development of Novel AAV Serotype 6 Based Vectors With Selective Tropism for Human Cancer Cells. Gene Therapy. 23:18-25. 2016
- Strategies to Generate High-Titer, High-Potency Recombinant Aav3 Serotype Vectors 2016
- Efficient and Targeted Transduction of Nonhuman Primate Liver With Systemically Delivered Optimized Aav3B Vectors. Molecular Therapy. 23:1867-1876. 2015
- Site-Directed Mutagenesis of Surface-Exposed Lysine Residues Leads to Improved Transduction By Aav2, But Not Aav8, Vectors in Murine Hepatocytes in Vivo. Human Gene Therapy Methods. 26:211-220. 2015
- Prevalence of neutralizing antibodies against liver-tropic adeno-associated virus serotype vectors in 100 healthy Chinese and its potential relation to body constitutions. Journal of Integrative Medicine (Shanghai). 341-6. 2015
- Productive Life Cycle of Adeno-Associated Virus Serotype 2 in the Complete Absence of a Conventional Polyadenylation Signal. Journal of General Virology. 96:2780-2787. 2015
- Productive Life Cycle of Adeno-Associated Virus Serotype 2 in the Complete Absence of a Conventional Polyadenylation Signal. Journal of General Virology. 96:2780-2787. 2015
- Reprogramming Immune Response With Capsid-Optimized Aav6 Vectors for Immunotherapy of Cancer. Journal of Immunotherapy. 38:292-298. 2015
- The Adeno-Associated Virus Genome Packaging Puzzle. Journal of molecular and genetic medicine. 2015
- Neuritin Reverses Deficits in Murine Novel Object Associative Recognition Memory Caused By Exposure to Extremely Low-Frequency (50 Hz) Electromagnetic Fields. Scientific Reports. 5. 2015
- Enhanced Transgene Expression From Recombinant Single-Stranded D-Sequence-Substituted Adeno-Associated Virus Vectors in Human Cell Lines in Vitro and in Murine Hepatocytes in Vivo. Journal Of Virology. 89:952-961. 2015-01-01
- Enhanced Transgene Expression From Recombinant Single-Stranded D-Sequence-Substituted Adeno-Associated Virus Vectors in Human Cell Lines in Vitro and in Murine Hepatocytes in Vivo. Journal Of Virology. 89:952-961. 2015-01-01
- Selective in Vivo Targeting of Human Liver Tumors By Optimized Aav3 Vectors in a Murine Xenograft Model. Human Gene Therapy. 25:1023-1034. 2014-12-01
- Selective in Vivo Targeting of Human Liver Tumors By Optimized Aav3 Vectors in a Murine Xenograft Model. Human Gene Therapy. 25:1023-1034. 2014-12-01
- Cytotoxic genes from traditional Chinese medicine inhibit tumor growth both in vitro and in vivo. Journal of Integrative Medicine (Shanghai). 483-94. 2014
- Three advantages of using traditional Chinese medicine to prevent and treat tumor. Journal of Integrative Medicine (Shanghai). 331-5. 2014
- The roles of traditional Chinese medicine in gene therapy. Journal of Integrative Medicine (Shanghai). 67-75. 2014
- Template-Synthesized Lignin Nanotubes as Vehicles for Smart Delivery of Dna Into Human Cells 2014-03-01
- Rationally Designed Capsid and Transgene Cassette of Aav6 Vectors for Dendritic Cell-Based Cancer Immunotherapy. Immunology and Cell Biology. 92:116-123. 2014-02-01
- Pristimerin enhances recombinant adeno-associated virus vector-mediated transgene expression in human cell lines in vitro and murine hepatocytes in vivo. Journal of Integrative Medicine (Shanghai). 20-34. 2014
- Lignin Nanotubes as Vehicles for Gene Delivery Into Human Cells. Biomacromolecules. 15:327-338. 2014-01-01
- Molecular Cloning, Overexpression, and An Efficient One-Step Purification of Alpha 5 Beta 1 Integrin. Protein Expression and Purification. 92:21-28. 2013-11-01
- Development of Lignin Nanotubes for the Smart Delivery of Therapeutic Agents 2013-09-01
- Optimizing the Transduction Efficiency of Capsid-Modified Aav6 Serotype Vectors in Primary Human Hematopoietic Stem Cells in Vitro and in a Xenograft Mouse Model in Vivo. Cytotherapy. 15:986-998. 2013-08-01
- Functional Roles of the Aav2 Inverted Terminal Repeat in Messenger Rna Transport and Transgene Expression. Molecular Therapy. 21:S30-S31. 2013-06-01
- Functional Roles of the Aav2 Inverted Terminal Repeat in Messenger Rna Transport and Transgene Expression. Molecular Therapy. 21:S30-S31. 2013-06-01
- High-Efficiency Transduction of Primary Human Hematopoietic Stem Cells and Erythroid Lineage-Restricted Expression By Optimized Scaav6 Serotype Vectors in Vitro and in a Murine Xenograft Model in Vivo. Molecular Therapy. 21:S126-S127. 2013-06-01
- High-Efficiency Transduction of Primary Human Hematopoietic Stem Cells and Erythroid Lineage-Restricted Expression By Optimized Scaav6 Serotype Vectors in Vitro and in a Murine Xenograft Model in Vivo. Molecular Therapy. 21:S126-S127. 2013-06-01
- High-Efficiency Transduction of Primary Human Monocyte-Derived Dendritic Cells By Recombinant Aav6 Vectors Containing Mutations in Surface-Exposed Serine and Threonine Residues. Molecular Therapy. 21:S129. 2013-06-01
- Optimization of the Capsid of Recombinant Adeno-Associated Virus 2 Vectors: the Final Threshold?. Molecular Therapy. 21:S129. 2013-06-01
- Pristimerin Enhances Recombinant Adeno-Associated Virus Serotype 2 Vector-Mediated Transgene Expression Both in Vitro and in Vivo. Molecular Therapy. 21:S121. 2013-06-01
- Pristimerin Enhances Recombinant Adeno-Associated Virus Serotype 2 Vector-Mediated Transgene Expression Both in Vitro and in Vivo. Molecular Therapy. 21:S121. 2013-06-01
- Productive Life Cycle of the Aav2 in the Complete Absence of a Conventional Polyadenylation Signal. Molecular Therapy. 21:S49. 2013-06-01
- Productive Life Cycle of the Aav2 in the Complete Absence of a Conventional Polyadenylation Signal. Molecular Therapy. 21:S49. 2013-06-01
- Site-Directed Mutagenesis of Surface-Exposed Lysine Residues Leads To Improved Transduction By Recombinant Aav2 and Aav8 Vectors in Murine Hepatocytes in Vivo. Molecular Therapy. 21:S208-S209. 2013-06-01
- Transduction of Murine, Nonhuman Primate, and Human Hematopoietic Stem Cells (Hscs) By Recombinant Aav Serotype Vectors: Identification of Aav6 as the Most Efficient Serotype for Human Hscs, and Further Augmentation in Transduction Efficiency in Vitro and in Vivo With Point-Mutations of Tyrosine Residues in the Viral Capsid. Molecular Therapy. 21:S209. 2013-06-01
- High-Efficiency Transduction of Primary Human Hematopoietic Stem Cells and Erythroid Lineage-Restricted Expression By Optimized Aav6 Serotype Vectors in Vitro and in a Murine Xenograft Model in Vivo. PLoS One. 8. 2013-03-01
- High-Efficiency Transduction of Primary Human Hematopoietic Stem Cells and Erythroid Lineage-Restricted Expression By Optimized Aav6 Serotype Vectors in Vitro and in a Murine Xenograft Model in Vivo. PLoS One. 8. 2013-03-01
- Optimization of the Capsid of Recombinant Adeno-Associated Virus 2 (Aav2) Vectors: the Final Threshold?. PLoS One. 8. 2013-03-01
- Limitations of Encapsidation of Recombinant Self-Complementary Adeno-Associated Viral Genomes in Different Serotype Capsids and Their Quantitation. Human Gene Therapy Methods. 23:225-233. 2012-08-01
- Limitations of Encapsidation of Recombinant Self-Complementary Adeno-Associated Viral Genomes in Different Serotype Capsids and Their Quantitation. Human Gene Therapy Methods. 23:225-233. 2012-08-01
- High-Efficiency Transduction of Human Monocyte-Derived Dendritic Cells By Capsid-Modified Recombinant Aav2 Vectors. Vaccine. 30:3908-3917. 2012-06-01
- High-Efficiency Transduction of Primary Human Hematopoietic Stem Cells By Optimized Aav6 Serotype Vectors and Erythroid Lineage-Restricted Transcriptional Targeting Using the Human Parvovirus B19 Promoter. Molecular Therapy. 20:S48-S49. 2012-05-01
- Limitations of Encapsidation of Recombinant Scaav2 Genomes in Different Serotype Capsids and Their Quantitation. Molecular Therapy. 20:S47. 2012-05-01
- Limitations of Encapsidation of Recombinant Scaav2 Genomes in Different Serotype Capsids and Their Quantitation. Molecular Therapy. 20:S47. 2012-05-01
- Mechanism of Transduction of Human Hematopoietic Cells By Recombinant Aav6 Vectors. Molecular Therapy. 20:S229-S230. 2012-05-01
- Mechanism of Transduction of Human Hematopoietic Cells By Recombinant Aav6 Vectors. Molecular Therapy. 20:S229-S230. 2012-05-01
- Site-Directed Mutagenesis of Surface-Exposed Tyrosine, Serine, and Threonine Residues Leads To High-Efficiency Transduction By Recombinant Adeno-Associated Virus 2 Vectors. Molecular Therapy. 20:S48. 2012-05-01
- Development of Optimized Aav3 Serotype Vectors: Mechanism of High-Efficiency Transduction of Human Liver Cancer Cells. Gene Therapy. 19:375-384. 2012-04-01
- A Simple Method To Increase the Transduction Efficiency of Single-Stranded Adeno-Associated Virus Vectors in Vitro and in Vivo. Human Gene Therapy. 22:633-640. 2011-05-01
- High-efficiency transduction of liver cancer cells by recombinant adeno-associated virus serotype 3 vectors 2011
- High-Efficiency Transduction and Correction of Murine Hemophilia B Using Aav2 Vectors Devoid of Multiple Surface-Exposed Tyrosines. Molecular Therapy. 18:2048-2056. 2010-12-01
- Human Hepatocyte Growth Factor Receptor Is a Cellular Coreceptor for Adeno-Associated Virus Serotype. Human Gene Therapy. 21:1741-1747. 2010-12-01
- Human Hepatocyte Growth Factor Receptor Is a Cellular Coreceptor for Adeno-Associated Virus Serotype. Human Gene Therapy. 21:1741-1747. 2010-12-01
- High-Efficiency Transduction of Fibroblasts and Mesenchymal Stem Cells By Tyrosine-Mutant Aav2 Vectors for Their Potential Use in Cellular Therapy. Human Gene Therapy. 21:1527-1543. 2010-11-01
- Negative Autoregulation of Epstein-Barr Virus (Ebv) Replicative Gene Expression By Ebv Sm Protein. Journal Of Virology. 83:8041-8050. 2009-08-01
- Human Hematopoietic Stem Cell Transduction By Aav Vectors: Identification of Aav6 as the Most Efficient Serotype, and Further Augmentation in Transduction Efficiency With Point-Mutations At Tyrosine Residues 705 and 731 in the Viral Capsid. Molecular Therapy. 17:372. 2009-05-01
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editorial article
- Rational Design of Gene Therapy Vectors. Molecular Therapy-Methods & Clinical Development. 2019
Research
principal investigator on
- Development of AAV Vectors for Efficient Targeting and Elimination of Osteosarcoma Tumor-Initiating Cells awarded by Alex's Lemonade Stand Foundation 2014 - 2016
- Treatment for Human Hepatocellular Carcinoma Based on Genome& Capsid-Optimized Recombinant Adeno-Associate Virus Serotype... awarded by Bankhead-Coley Cancer Research Program 2012 - 2015
- Gene Therapy for Human Hepatoblastoma Based on Recombinant Adeno-Associated Virus Vectors awarded by Alex's Lemonade Stand Foundation 2012 - 2014
- Hematopoietic Stem Cell Transduction By AAV Vectors awarded by University of Florida Medical Guild 2009 - 2010
Contact
full name
- Changquan Ling
- Chen Ling
- Changquan Ling
- Changquan Ling
- Chen Ling
- Changquang Ling
- Changquan Ling
- Changquan Ling
- Chen Ling
- Changquan Ling
- Changquan Ling
- Changquan Ling
- Changquan Ling
- Changquan Ling
primary email
- littlefrog@ufl.edu
phone
- (352) 273-8253
Publications in VIVO
- Contact Info
- (352) 273-8253