overview Research in the Wang Lab focuses on understanding the pathogenesis and molecular biology of viruses that cause chronic human infections, in particular, human immunodeficiency virus and Hepatitis C virus (HCV).
has course role ALS4905 Problems In Agricul BMS6300C Med Micrbio/infec Dis BMS6834 Essen Patient Care 4 IDH4917 Undergrad Research MEL7948 Elect Top/medicine PAS5020 Intro To Medicine 2
selected publications academic article Pneumocystis jirovecii pneumonia presenting as a large pulmonary mass in a patient with AIDS. BMJ Case Reports. 2023 Analysis of Tryptophan Metabolites in Serum Using Wide-Isolation Strategies for UHPLC-HRMS/MS. Analytical chemistry. 2020 A single variant sequencing method for sensitive and quantitative detection of HIV-1 minority variants. Scientific Reports. 10:8185. 2020 Muscadine Grapes (Vitis rotundifolia) and Dealcoholized Muscadine Wine Alleviated Symptoms of Colitis and Protected Against Dysbiosis in Mice Exposed to Dextran Sulfate Sodium. Journal of Functional Foods. 65:103746. 2020 Decreased ω-6:ω-3 PUFA ratio attenuates ethanol-induced alterations in intestinal homeostasis, microbiota, and liver injury 2019 Efficacy of Glecaprevir and Pibrentasvir in Patients With Genotype 1 Hepatitis C Virus Infection With Treatment Failure After NS5A Inhibitor Plus Sofosbuvir Therapy 2019 Upper versus lower airway microbiome and metagenome in children with cystic fibrosis and their correlation with lung inflammation. PLoS One. e0222323. 2019 Molecular Identification of Bacteria in Intra-abdominal Abscesses Using Deep Sequencing 2018 The Subgingival Microbiome in Patients With Established Rheumatoid Arthritis. Rheumatology (Oxford, England). 57:1162-1172. 2018 Prevalence And Impact Of Baseline Resistance-Associated Substitutions On The Efficacy Of Ledipasvir/Sofosbuvir Or Simeprevir/Sofosbuvir Against Gt1 Hcv Infection.. Scientific Reports. 8:3199. 2018 Sofosbuvir (SOF) Suppresses Ledipasvir (LDV)-resistant Mutants during SOF/LDV Combination Therapy against Genotype 1b Hepatitis C Virus (HCV). Scientific Reports. 14421. 2017 Shifts in the Gut Microbiota Composition Due to Depleted Bone Marrow Beta Adrenergic Signaling Are Associated With Suppressed Inflammatory Transcriptional Networks in the Mouse Colon. Frontiers in physiology. 8. 2017 Sequencing of hepatitis c virus for detection of resistance to direct-acting therapy: A systematic review. 2017 Shifts in the Gut Microbiota Composition Due to Depleted Bone Marrow Beta Adrenergic Signaling Are Associated With Suppressed Inflammatory Transcriptional Networks in the Mouse Colon. Frontiers in physiology. 8:220. 2017 Shifts in the gut microbiota composition due to depleted bone marrow beta adrenergic signaling are associated with suppressed inflammatory transcriptional networks in the mouse colon. Frontiers in physiology. 8. 2017 Locoregional Effects Of Microbiota In A Preclinical Model Of Colon Carcinogenesis. 2017 Cd4(+) T-Cell Recovery With Suppressive Art-Induced Rapid Sequence Evolution in Hepatitis C Virus Envelope But Not Ns3. Aids. 30:691-700. 2016 An Integrated Metabolomic and Microbiome Analysis Identified Specific Gut Microbiota Associated With Fecal Cholesterol and Coprostanol in Clostridium Difficile Infection. PLoS One. 11. 2016 Biofilm Formation by Mycobacterium abscessus in a lung cavity. American Journal of Respiratory and Critical Care Medicine. 193:692-693. 2016 Defining Functional Signatures of Dysbiosis in Periodontitis Progression. Genome Medicine. 7. 2015-04-01 Dysbiosis and alterations in predicted functions of the subgingival microbiome in chronic periodontitis. Applied and Environmental Microbiology. 2015 Colonic Immune Suppression, Barrier Dysfunction, and Dysbiosis By Gastrointestinal Bacillus Anthracis Infection. PLoS One. 9. 2014-06-01 Epithelial CaSR deficiency alters intestinal integrity and promotes proinflammatory immune responses 2014 Patient Preferences and Compliance With Oral Vancomycin Solution for the Management of Clostridium Difficile Infection. American Journal of Gastroenterology. 108:S169. 2013-10-01 Intestinal Dysbiosis and Depletion of Butyrogenic Bacteria in Clostridium Difficile Infection and Nosocomial Diarrhea. Journal of Clinical Microbiology. 51:2884-2892. 2013-09-01 Deep Sequencing Analysis of Hcv Ns3 Resistance-Associated Variants and Mutation Linkage in Liver Transplant Recipients. PLoS One. 8. 2013-07-01 Loop residues and catalysis in OMP synthase. Biochemistry. 51:4406-4415. 2012 A method to sequence and quantify DNA integration for monitoring outcome in gene therapy 2011 Loss of p19Arf in a Rag1(-/-) B-cell precursor population initiates acute B-lymphoblastic leukemia. Blood. 118:544-553. 2011 Dynamics of gene-modified progenitor cells analyzed by tracking retroviral integration sites in a human SCID-X1 gene therapy trial. Blood. 115:4356-4366. 2010 Efficacy of gene therapy for X-linked severe combined immunodeficiency. New England Journal of Medicine. 363:355-364. 2010 Hepatitis C virus transmission bottlenecks analyzed by deep sequencing. Journal Of Virology. 84:6218-6228. 2010 Transfusion independence and HMGA2 activation after gene therapy of human b-thalassaemia. Nature. 467:318-322. 2010 Leukemia Prone B-Precursor Population in a P19Arf-/-Rag1-/- Mouse Model. Blood. 114:1527. 2009-11-01 Analysis of lentiviral vector integration in HIV+ study subjects receiving autologous infusions of gene modified CD4+ T cells. Molecular Therapy : The Journal Of The American Society Of Gene Therapy. 17:844-850. 2009 Methods for integration site distribution analyses in animal cell genomes. Methods (San Diego, Calif.). 47:261-268. 2009 DNA bar coding and pyrosequencing to analyze adverse events in therapeutic gene transfer. Nucleic Acids Research. 36:e49. 2008 Insertional oncogenesis in 4 patients after retrovirus-mediated gene therapy of SCID-X1. The Journal Of Clinical Investigation. 118:3132-3142. 2008 massively parallel pyrosequencing in HIV research. Aids. 22:1411-1415. 2008 DNA bar coding and pyrosequencing to identify rare HIV drug resistance mutations. Nucleic Acids Research. 35:e91. 2007 HIV integration site selection: analysis by massively parallel pyrosequencing reveals association with epigenetic modifications. Genome Research. 17:1186-1194. 2007 A statistical method for comparing viral growth curves. Journal of virological methods. 135:118-123. 2006 Kinetic mechanism of OMP synthase: a slow physical step following group transfer limits catalytic rate. Biochemistry. 38:275-283. 1999 motional dynamics of the catalytic loop in OMP synthase. Biochemistry. 38:275-283. 1999 Making a nucleotide: structure and function of orotate phosphoribosyltransferase 1998 Local effect of glycine substitution in a model helical peptide. Journal of the American Chemical Society. 113:3568-3572. 1991 editorial article Biofilm Formation By Mycobacterium Abscessus in a Lung Cavity. American Journal of Respiratory and Critical Care Medicine. 193:692-693. 2016 Biofilm Formation By Mycobacterium Abscessus in a Lung Cavity. American Journal of Respiratory and Critical Care Medicine. 193:692-693. 2016
principal investigator on Naturally Occurring Mutations to Hepatitis C Virus Protease Inhibitors Analyzed By Deep Sequencing awarded by Schering Plough Research Institute 2011 - 2016 Human Oral Microbiome in Periodontal Disease and HIV Infection awarded by National Institute of Dental and Craniofacial Research 2010 - 2013 HCV Diversity and Resistance Analyzed By DNA Bar Coding and Pyrosequencing awarded by National Institute of Allergy and Infectious Diseases Molecular Ecology of Gut Microbiota in Recurrent C Difficileinfection awarded by Merck Sharp and Dohme Molecular Identification of Subjingival Bacteria Associated With Progression of Periodontitis in Smokers awarded by Florida Department of Health J and E King Biomedical Research Program
investigator on Optimizing Combination Therapy for Hepatitis C Virus With Pharmacodynamic Models awarded by National Institute of Allergy and Infectious Diseases 2014 - 2019
teaching activities ALS4905 Spring 2010 1344 ALS4905 Spring 2010 1344 BMS6300C Fall 2009 8591 BMS6300C Fall 2009 8591 BMS6300C Fall 2011 8591 BMS6300C Fall 2011 8591 BMS6834 Spring 2011 6935 BMS6834 Spring 2011 6935 IDH4917 Fall 2010 0335 IDH4917 Fall 2010 0335 IDH4917 Spring 2011 2151 IDH4917 Spring 2011 2151 MEL7948 Fall 2009 2356 MEL7948 Fall 2009 2356 MEL7948 Fall 2010 2356 MEL7948 Fall 2010 2356 MEL7948 Spring 2010 8565 MEL7948 Spring 2010 8565 PAS5020 Spring 2011 1169 PAS5020 Spring 2011 1169
education and training B.A. in Chemistry, Cornell University , College of Arts and Sciences M.D., Temple University School of Medicine Ph.D. in Biochemistry, Temple University School of Medicine