subject area of Age-Related Activation of Mitochondrial Caspase-Independent Apoptotic Signaling in Rat Gastrocnemius Muscle Academic Article Age-Related Hearing Loss in C57Bl/6J Mice Is Mediated By Bak-Dependent Mitochondrial Apoptosis Academic Article Amifostine Acts Upon Mitochondria To Stimulate Growth of Bone Marrow and Regulate Cytokines Conference Paper An Exploratory Analysis of the Effects of a Weight Loss Plus Exercise Program On Cellular Quality Control Mechanisms in Older Overweight Women Academic Article Angiosperm Phylogeny: 17 Genes, 640 Taxa Academic Article Autophagy in the Retina: a Potential Role in Age-Related Macular Degeneration Academic Article Bcl-2 Proteins Egl-1 and Ced-9 Do Not Regulate Mitochondrial Fission Or Fusion in Caenorhabditis Elegans Academic Article Beneficial Effects of a Q-Ter (R) Based Nutritional Mixture On Functional Performance, Mitochondrial Function, and Oxidative Stress in Rats Academic Article Brain Metabolic and Hemodynamic Effects of Cyclosporin a After Human Severe Traumatic Brain Injury: a Microdialysis Study Academic Article Caenorhabditis Elegans Drp-1 and Fis-2 Regulate Distinct Cell-Death Execution Pathways Downstream of Ced-3 and Independent of Ced-9 Academic Article Changes in mitochondrial membrane potential and accumulation of reactive oxygen species precede ultrastructural changes during ovule abortion. Academic Article Characterization of a Transgenic Short Hairpin Rna-Induced Murine Model of Tafazzin Deficiency Academic Article Cheating Death At the Dawn of Life: Developmental Control of Apoptotic Repression in the Preimplantation Embryo Academic Article Cigarette Smoke Decreases Mitochondrial Porin Expression and Steroidogenesis Academic Article Combination Therapy Targeting Cancer Metabolism Academic Article Complex II of the Mitochondrial Respiratory Chain Is the Key Mediator of Divalent Manganese-Induced Hydrogen Peroxide Production in Microglia Academic Article Delayed Effects of Radiation On Mitochondrial Dna in Radiation-Sensitive Organs Academic Article Development of Diabetes in Lean Ncb5Or-Null Mice Is Associated With Manifestations of Endoplasmic Reticulum and Oxidative Stress in Beta Cells Academic Article Do-It-Yourself (Diy) Pathology Academic Article Effects of acute ethanol exposure on regulatory mechanisms of Bcl-2-associated apoptosis promoter, bad, in neonatal rat cerebellum: differential effects during vulnerable and resistant developmental periods. Academic Article Efficiency and Safety of Aav-Mediated Gene Delivery of the Human Nd4 Complex I Subunit in the Mouse Visual System Academic Article Endurance Exercise Attenuates Ventilator-Induced Diaphragm Dysfunction Academic Article Evaluation of Choroidal Endothelial Cell Proliferation After Exposure To Varying Doses of Proton Beam Radiation Academic Article Exercise preconditioning of the myocardium. Academic Article Expression of Mutant Tdp-43 Induces Neuronal Dysfunction in Transgenic Mice Academic Article Feline Non-Repetitive Mitochondrial Dna Control Region Database for Forensic Evidence Academic Article Folding, activity and import of steroidogenic acute regulatory protein into mitochondria changed by nicotine exposure. Academic Article Functional Expression of Human Adenine Nucleotide Translocase 4 in Saccharomyces Cerevisiae Academic Article Gene Delivery To Mitochondria By Targeting Modified Adenoassociated Virus Suppresses Leber'S Hereditary Optic Neuropathy in a Mouse Model Academic Article Gene Therapy With Mitochondrial Heat Shock Protein 70 Suppresses Visual Loss and Optic Atrophy in Experimental Autoimmune Encephalomyelitis Academic Article Glucose Oxidation Modulates Anoikis and Tumor Metastasis Academic Article Hyperglycemia-Induced Endoplasmic Reticulum Stress in Endothelial Cells Academic Article Hyperglycemia-Induced Reactive Oxygen Species Toxicity To Endothelial Cells Is Dependent On Paracrine Mediators Academic Article Identification of Mitochondrial Thiamin Diphosphate Carriers From Arabidopsis and Maize Academic Article Identification of Unknown Protein Complex Members By Radiolocalization and Analysis of Low-Abundance Complexes Resolved Using Native Polyacrylamide Gel Electrophoresis Academic Article Inactivation of Hnrnp K By Expanded Intronic Auucu Repeat Induces Apoptosis Via Translocation of Pkc Delta To Mitochondria in Spinocerebellar Ataxia 10 Academic Article Independent Gene Duplications of the Yidc/Oxa/Alb3 Family Enabled a Specialized Cotranslational Function Academic Article Induction of Reactive Oxygen Species-Mediated Autophagy By a Novel Microtubule-Modulating Agent Academic Article Interleukin 11 Protects Bone Marrow Mitochondria From Radiation Damage Conference Paper Lhon Gene Therapy Vector Prevents Visual Loss and Optic Neuropathy Induced By G11778a Mutant Mitochondrial Dna: Biodistribution and Toxicology Profile Academic Article MRI in experimental inflammatory and mitochondrial optic neuropathies. Academic Article Magnetic resonance spectroscopic investigation of mitochondrial fuel metabolism and energetics in cultured human fibroblasts: effects of pyruvate dehydrogenase complex deficiency and dichloroacetate. Academic Article Manganese Superoxide Dismutase Promotes Anoikis Resistance and Tumor Metastasis Academic Article Manipulations in the Peripheral Stalk of the Saccharomyces Cerevisiae F(1)F(0)-Atp Synthase Academic Article Metabolic Regulation of Manganese Superoxide Dismutase Expression Via Essential Amino Acid Deprivation Academic Article Metabolism of the Folate Precursor P-Aminobenzoate in Plants - Glucose Ester Formation and Vacuolar Storage Academic Article Mice Expressing An Error-Prone Dna Polymerase in Mitochondria Display Elevated Replication Pausing and Chromosomal Breakage At Fragile Sites of Mitochondrial Dna Academic Article Mitochondrial Abnormalities, Energy Deficit and Oxidative Stress Are Features of Calpain 3 Deficiency in Skeletal Muscle Academic Article Mitochondrial Dna Mutations Induce Mitochondrial Dysfunction, Apoptosis and Sarcopenia in Skeletal Muscle of Mitochondrial Dna Mutator Mice Academic Article Mitochondrial Impacts of Insecticidal Formate Esters in Insecticide-Resistant and Insecticide-Susceptible Drosophila Melanogaster Academic Article Mitochondrial Pathways in Sarcopenia of Aging and Disuse Muscle Atrophy Academic Article Mitochondrial and Plastidial Cog0354 Proteins Have Folate-Dependent Functions in Iron-Sulphur Cluster Metabolism Academic Article Mitochondrial depolarization following hydrogen sulfide exposure in erythrocytes from a sulfide-tolerant marine invertebrate. Academic Article Molecular Mechanism of Reduction in Pregnenolone Synthesis By Cigarette Smoke Academic Article Mouse Models of Age-Related Mitochondrial Neurosensory Hearing Loss Academic Article Mt-Nd2(A) Suppresses Reactive Oxygen Species Production By Mitochondrial Complexes I and Iii Academic Article Neuronal Sensitivity To Tdp-43 Overexpression Is Dependent On Timing of Induction Academic Article Nitric Oxide and Ampk Cooperatively Regulate Pgc-1 Alpha in Skeletal Muscle Cells Academic Article Nitric oxide-induced persistent inhibition and nitrosylation of active site cysteine residues of mitochondrial cytochrome-c oxidase in lung endothelial cells. Academic Article Oncogenic Kras Modulates Mitochondrial Metabolism in Human Colon Cancer Cells By Inducing Hif-1 Alpha and Hif-2 Alpha Target Genes Academic Article Opa1 Downregulation Is Involved in Sorafenib-Induced Apoptosis in Hepatocellular Carcinoma Academic Article Optic Nerve Degeneration in Experimental Autoimmune Encephalomyelitis Academic Article Parkin Is Transcriptionally Regulated By Atf4: Evidence for An Interconnection Between Mitochondrial Stress and Er Stress Academic Article Pathological Consequences of Long-Term Mitochondrial Oxidative Stress in the Mouse Retinal Pigment Epithelium Academic Article Perception and Degradation of N-Acyl Homoserine Lactone Quorum Sensing Signals By Mammalian and Plant Cells Academic Article Permafrost Degradation Stimulates Carbon Loss From Experimentally Warmed Tundra Academic Article Pharmacological Rescue of Mitochondrial Deficits in Ipsc-Derived Neural Cells From Patients With Familial Parkinson'S Disease Academic Article Porphyromonas Gingivalis-Nucleoside-Diphosphate-Kinase Inhibits Atp-Induced Reactive-Oxygen-Species Via P2X(7) Receptor/Nadph-Oxidase Signalling and Contributes To Persistence Academic Article Preliminary Insights Into the Phylogeography of the Yellow-Bellied Sea Snake, Pelamis Platurus Academic Article Prevention of Gentamicin-Induced Apoptosis With the Mitochondria-Targeted Antioxidant Mitoquinone Academic Article Properties of human mitochondrial ribosomes. Academic Article Protective effects of polysaccharide from Euphorbia kansui (Euphorbiaceae) on the swimming exercise-induced oxidative stress in mice. Academic Article Radiation Affects the Responsiveness of Bone Marrow To G-Csf Conference Paper Receptor Tyrosine Kinase Erbb2 Translocates Into Mitochondria and Regulates Cellular Metabolism Academic Article Role of Genetics in Resistance To Type 1 Diabetes Academic Article Role of Mitochondrial Dysfunction and Altered Autophagy in Cardiovascular Aging and Disease: From Mechanisms To Therapeutics Academic Article Role of the Mitochondria in Immune-Mediated Apoptotic Death of the Human Pancreatic Beta Cell Line Beta Lox5 Academic Article Silencing of Ptk7 in Colon Cancer Cells: Caspase-10-Dependent Apoptosis Via Mitochondrial Pathway Academic Article Sirt3 Mediates Reduction of Oxidative Damage and Prevention of Age-Related Hearing Loss Under Caloric Restriction Academic Article Skeletal muscle apoptosis, sarcopenia and frailty at old age. Academic Article Steroidogenic Activity of Star Requires Contact With Mitochondrial Vdac1 and Phosphate Carrier Protein Academic Article Subsarcolemmal and Intermyofibrillar Mitochondria Proteome Differences Disclose Functional Specializations in Skeletal Muscle Academic Article Substrate Metabolism During Basal and Hyperinsulinemic Conditions in Adolescents and Young-Adults With Barth Syndrome Academic Article Symbionts, Including Pathogens, of the Predatory Mite Metaseiulus Occidentalis: Current and Future Analysis Methods Academic Article Taxonomy of Lice and Their Endosymbiotic Bacteria in the Post-Genomic Era Academic Article Teleost Fish Osmoregulation: What Have We Learned Since August Krogh, Homer Smith, and Ancel Keys Academic Article Testing Hypotheses About the Sister Group of the Passeriformes Using An Independent 30-Locus Data Set Academic Article The C-Terminal Transmembrane Domain of Bcl-X(L) Mediates Changes in Mitochondrial Morphology Academic Article The E163K DJ-1 mutant shows specific antioxidant deficiency Academic Article The Emerging Role of Iron Dyshomeostasis in the Mitochondrial Decay of Aging Academic Article The Importance of Long-Distance Seed Dispersal for the Demography and Distribution of a Canopy Tree Species Academic Article The Importance of Mitochondria in Age-Related and Inherited Eye Disorders Academic Article The Pyruvate Dehydrogenase Complex as a Therapeutic Target for Age-Related Diseases Academic Article The Role of Mitochondrial Dna Mutations in Aging and Sarcopenia: Implications for the Mitochondrial Vicious Cycle Theory of Aging Academic Article The Role of Mitochondrial Proteomic Analysis in Radiological Accidents and Terrorism Academic Article Two New Species of Torodora Meyrick (Lepidoptera, Lecithoceridae) and Two Species New To Taiwan Academic Article Uric Acid Induces Hepatic Steatosis By Generation of Mitochondrial Oxidative Stress Potential Role in Fructose-Dependent and -Independent Fatty Liver Academic Article Variable Microsatellite Loci for Population Genetic Analysis of Old World Monkey Lice (Pedicinus Sp.) Academic Article Wild-type human TDP-43 expression causes TDP-43 phosphorylation, mitochondrial aggregation, motor deficits, and early mortality in transgenic mice Academic Article
subjectAreaFor Age-Related Activation of Mitochondrial Caspase-Independent Apoptotic Signaling in Rat Gastrocnemius Muscle Academic Article Age-Related Hearing Loss in C57Bl/6J Mice Is Mediated By Bak-Dependent Mitochondrial Apoptosis Academic Article Amifostine Acts Upon Mitochondria To Stimulate Growth of Bone Marrow and Regulate Cytokines Conference Paper An Exploratory Analysis of the Effects of a Weight Loss Plus Exercise Program On Cellular Quality Control Mechanisms in Older Overweight Women Academic Article Angiosperm Phylogeny: 17 Genes, 640 Taxa Academic Article Autophagy in the Retina: a Potential Role in Age-Related Macular Degeneration Academic Article Bcl-2 Proteins Egl-1 and Ced-9 Do Not Regulate Mitochondrial Fission Or Fusion in Caenorhabditis Elegans Academic Article Beneficial Effects of a Q-Ter (R) Based Nutritional Mixture On Functional Performance, Mitochondrial Function, and Oxidative Stress in Rats Academic Article Brain Metabolic and Hemodynamic Effects of Cyclosporin a After Human Severe Traumatic Brain Injury: a Microdialysis Study Academic Article Caenorhabditis Elegans Drp-1 and Fis-2 Regulate Distinct Cell-Death Execution Pathways Downstream of Ced-3 and Independent of Ced-9 Academic Article Changes in mitochondrial membrane potential and accumulation of reactive oxygen species precede ultrastructural changes during ovule abortion. Academic Article Characterization of a Transgenic Short Hairpin Rna-Induced Murine Model of Tafazzin Deficiency Academic Article Cheating Death At the Dawn of Life: Developmental Control of Apoptotic Repression in the Preimplantation Embryo Academic Article Cigarette Smoke Decreases Mitochondrial Porin Expression and Steroidogenesis Academic Article Combination Therapy Targeting Cancer Metabolism Academic Article Complex II of the Mitochondrial Respiratory Chain Is the Key Mediator of Divalent Manganese-Induced Hydrogen Peroxide Production in Microglia Academic Article Delayed Effects of Radiation On Mitochondrial Dna in Radiation-Sensitive Organs Academic Article Development of Diabetes in Lean Ncb5Or-Null Mice Is Associated With Manifestations of Endoplasmic Reticulum and Oxidative Stress in Beta Cells Academic Article Do-It-Yourself (Diy) Pathology Academic Article Effects of acute ethanol exposure on regulatory mechanisms of Bcl-2-associated apoptosis promoter, bad, in neonatal rat cerebellum: differential effects during vulnerable and resistant developmental periods. Academic Article Efficiency and Safety of Aav-Mediated Gene Delivery of the Human Nd4 Complex I Subunit in the Mouse Visual System Academic Article Endurance Exercise Attenuates Ventilator-Induced Diaphragm Dysfunction Academic Article Evaluation of Choroidal Endothelial Cell Proliferation After Exposure To Varying Doses of Proton Beam Radiation Academic Article Exercise preconditioning of the myocardium. Academic Article Expression of Mutant Tdp-43 Induces Neuronal Dysfunction in Transgenic Mice Academic Article Feline Non-Repetitive Mitochondrial Dna Control Region Database for Forensic Evidence Academic Article Folding, activity and import of steroidogenic acute regulatory protein into mitochondria changed by nicotine exposure. Academic Article Functional Expression of Human Adenine Nucleotide Translocase 4 in Saccharomyces Cerevisiae Academic Article Gene Delivery To Mitochondria By Targeting Modified Adenoassociated Virus Suppresses Leber'S Hereditary Optic Neuropathy in a Mouse Model Academic Article Gene Therapy With Mitochondrial Heat Shock Protein 70 Suppresses Visual Loss and Optic Atrophy in Experimental Autoimmune Encephalomyelitis Academic Article Glucose Oxidation Modulates Anoikis and Tumor Metastasis Academic Article Hyperglycemia-Induced Endoplasmic Reticulum Stress in Endothelial Cells Academic Article Hyperglycemia-Induced Reactive Oxygen Species Toxicity To Endothelial Cells Is Dependent On Paracrine Mediators Academic Article Identification of Mitochondrial Thiamin Diphosphate Carriers From Arabidopsis and Maize Academic Article Identification of Unknown Protein Complex Members By Radiolocalization and Analysis of Low-Abundance Complexes Resolved Using Native Polyacrylamide Gel Electrophoresis Academic Article Inactivation of Hnrnp K By Expanded Intronic Auucu Repeat Induces Apoptosis Via Translocation of Pkc Delta To Mitochondria in Spinocerebellar Ataxia 10 Academic Article Independent Gene Duplications of the Yidc/Oxa/Alb3 Family Enabled a Specialized Cotranslational Function Academic Article Induction of Reactive Oxygen Species-Mediated Autophagy By a Novel Microtubule-Modulating Agent Academic Article Interleukin 11 Protects Bone Marrow Mitochondria From Radiation Damage Conference Paper Lhon Gene Therapy Vector Prevents Visual Loss and Optic Neuropathy Induced By G11778a Mutant Mitochondrial Dna: Biodistribution and Toxicology Profile Academic Article MRI in experimental inflammatory and mitochondrial optic neuropathies. Academic Article Magnetic resonance spectroscopic investigation of mitochondrial fuel metabolism and energetics in cultured human fibroblasts: effects of pyruvate dehydrogenase complex deficiency and dichloroacetate. Academic Article Manganese Superoxide Dismutase Promotes Anoikis Resistance and Tumor Metastasis Academic Article Manipulations in the Peripheral Stalk of the Saccharomyces Cerevisiae F(1)F(0)-Atp Synthase Academic Article Metabolic Regulation of Manganese Superoxide Dismutase Expression Via Essential Amino Acid Deprivation Academic Article Metabolism of the Folate Precursor P-Aminobenzoate in Plants - Glucose Ester Formation and Vacuolar Storage Academic Article Mice Expressing An Error-Prone Dna Polymerase in Mitochondria Display Elevated Replication Pausing and Chromosomal Breakage At Fragile Sites of Mitochondrial Dna Academic Article Mitochondrial Abnormalities, Energy Deficit and Oxidative Stress Are Features of Calpain 3 Deficiency in Skeletal Muscle Academic Article Mitochondrial Dna Mutations Induce Mitochondrial Dysfunction, Apoptosis and Sarcopenia in Skeletal Muscle of Mitochondrial Dna Mutator Mice Academic Article Mitochondrial Impacts of Insecticidal Formate Esters in Insecticide-Resistant and Insecticide-Susceptible Drosophila Melanogaster Academic Article Mitochondrial Pathways in Sarcopenia of Aging and Disuse Muscle Atrophy Academic Article Mitochondrial and Plastidial Cog0354 Proteins Have Folate-Dependent Functions in Iron-Sulphur Cluster Metabolism Academic Article Mitochondrial depolarization following hydrogen sulfide exposure in erythrocytes from a sulfide-tolerant marine invertebrate. Academic Article Molecular Mechanism of Reduction in Pregnenolone Synthesis By Cigarette Smoke Academic Article Mouse Models of Age-Related Mitochondrial Neurosensory Hearing Loss Academic Article Mt-Nd2(A) Suppresses Reactive Oxygen Species Production By Mitochondrial Complexes I and Iii Academic Article Neuronal Sensitivity To Tdp-43 Overexpression Is Dependent On Timing of Induction Academic Article Nitric Oxide and Ampk Cooperatively Regulate Pgc-1 Alpha in Skeletal Muscle Cells Academic Article Nitric oxide-induced persistent inhibition and nitrosylation of active site cysteine residues of mitochondrial cytochrome-c oxidase in lung endothelial cells. Academic Article Oncogenic Kras Modulates Mitochondrial Metabolism in Human Colon Cancer Cells By Inducing Hif-1 Alpha and Hif-2 Alpha Target Genes Academic Article Opa1 Downregulation Is Involved in Sorafenib-Induced Apoptosis in Hepatocellular Carcinoma Academic Article Optic Nerve Degeneration in Experimental Autoimmune Encephalomyelitis Academic Article Parkin Is Transcriptionally Regulated By Atf4: Evidence for An Interconnection Between Mitochondrial Stress and Er Stress Academic Article Pathological Consequences of Long-Term Mitochondrial Oxidative Stress in the Mouse Retinal Pigment Epithelium Academic Article Perception and Degradation of N-Acyl Homoserine Lactone Quorum Sensing Signals By Mammalian and Plant Cells Academic Article Permafrost Degradation Stimulates Carbon Loss From Experimentally Warmed Tundra Academic Article Pharmacological Rescue of Mitochondrial Deficits in Ipsc-Derived Neural Cells From Patients With Familial Parkinson'S Disease Academic Article Porphyromonas Gingivalis-Nucleoside-Diphosphate-Kinase Inhibits Atp-Induced Reactive-Oxygen-Species Via P2X(7) Receptor/Nadph-Oxidase Signalling and Contributes To Persistence Academic Article Preliminary Insights Into the Phylogeography of the Yellow-Bellied Sea Snake, Pelamis Platurus Academic Article Prevention of Gentamicin-Induced Apoptosis With the Mitochondria-Targeted Antioxidant Mitoquinone Academic Article Properties of human mitochondrial ribosomes. Academic Article Protective effects of polysaccharide from Euphorbia kansui (Euphorbiaceae) on the swimming exercise-induced oxidative stress in mice. Academic Article Radiation Affects the Responsiveness of Bone Marrow To G-Csf Conference Paper Receptor Tyrosine Kinase Erbb2 Translocates Into Mitochondria and Regulates Cellular Metabolism Academic Article Role of Genetics in Resistance To Type 1 Diabetes Academic Article Role of Mitochondrial Dysfunction and Altered Autophagy in Cardiovascular Aging and Disease: From Mechanisms To Therapeutics Academic Article Role of the Mitochondria in Immune-Mediated Apoptotic Death of the Human Pancreatic Beta Cell Line Beta Lox5 Academic Article Silencing of Ptk7 in Colon Cancer Cells: Caspase-10-Dependent Apoptosis Via Mitochondrial Pathway Academic Article Sirt3 Mediates Reduction of Oxidative Damage and Prevention of Age-Related Hearing Loss Under Caloric Restriction Academic Article Skeletal muscle apoptosis, sarcopenia and frailty at old age. Academic Article Steroidogenic Activity of Star Requires Contact With Mitochondrial Vdac1 and Phosphate Carrier Protein Academic Article Subsarcolemmal and Intermyofibrillar Mitochondria Proteome Differences Disclose Functional Specializations in Skeletal Muscle Academic Article Substrate Metabolism During Basal and Hyperinsulinemic Conditions in Adolescents and Young-Adults With Barth Syndrome Academic Article Symbionts, Including Pathogens, of the Predatory Mite Metaseiulus Occidentalis: Current and Future Analysis Methods Academic Article Taxonomy of Lice and Their Endosymbiotic Bacteria in the Post-Genomic Era Academic Article Teleost Fish Osmoregulation: What Have We Learned Since August Krogh, Homer Smith, and Ancel Keys Academic Article Testing Hypotheses About the Sister Group of the Passeriformes Using An Independent 30-Locus Data Set Academic Article The C-Terminal Transmembrane Domain of Bcl-X(L) Mediates Changes in Mitochondrial Morphology Academic Article The E163K DJ-1 mutant shows specific antioxidant deficiency Academic Article The Emerging Role of Iron Dyshomeostasis in the Mitochondrial Decay of Aging Academic Article The Importance of Long-Distance Seed Dispersal for the Demography and Distribution of a Canopy Tree Species Academic Article The Importance of Mitochondria in Age-Related and Inherited Eye Disorders Academic Article The Pyruvate Dehydrogenase Complex as a Therapeutic Target for Age-Related Diseases Academic Article The Role of Mitochondrial Dna Mutations in Aging and Sarcopenia: Implications for the Mitochondrial Vicious Cycle Theory of Aging Academic Article The Role of Mitochondrial Proteomic Analysis in Radiological Accidents and Terrorism Academic Article Two New Species of Torodora Meyrick (Lepidoptera, Lecithoceridae) and Two Species New To Taiwan Academic Article Uric Acid Induces Hepatic Steatosis By Generation of Mitochondrial Oxidative Stress Potential Role in Fructose-Dependent and -Independent Fatty Liver Academic Article Variable Microsatellite Loci for Population Genetic Analysis of Old World Monkey Lice (Pedicinus Sp.) Academic Article Wild-type human TDP-43 expression causes TDP-43 phosphorylation, mitochondrial aggregation, motor deficits, and early mortality in transgenic mice Academic Article