abstract
- The 5-lipoxygenase (5LO) enzyme is upregulated in Alzheimer disease (AD), and its genetic absence reduces Aβ levels in APP mice. However, its functional role in modulating tau neuropathology remains to be elucidated.
5-Lipoxygenase Gene Transfer Worsens Memory, Amyloid, and Tau Brain Pathologies in a Mouse Model of Alzheimer Disease
Academic Article
Overview
authors
publication date
- 2012-09-01
has subject area
- ADAM Proteins
- Alzheimer Disease
- Amyloid Precursor Protein Secretases
- Amyloid beta-Peptides
- Amyloid beta-Protein Precursor
- Animals
- Arachidonate 5-Lipoxygenase
- Aspartic Acid Endopeptidases
- Brain
- Cells, Cultured
- Cyclin-Dependent Kinase 5
- Disease Models, Animal
- Enzyme-Linked Immunosorbent Assay
- Gene Expression Regulation
- Humans
- Maze Learning
- Membrane Proteins
- Memory Disorders
- Mice
- Mice, Transgenic
- NFI Transcription Factors
- Peptide Fragments
- Phosphorylation
- Presenilin-1
- Radioimmunoassay
- Random Allocation
- Signal Transduction
- Transfection
- tau Proteins
published in
- Annals of Neurology Journal
Identity
NIH Manuscript Submission System ID
- NIHMS375824
PubMed Central ID
- PMC3464917
Web of Science ID
- 000309405600019
grantCited
- AG18454
- AG20206
- AG33568
- R01 AG033568
Digital Object Identifier (DOI)
PubMed ID
- 23034916
Additional Document Info
start page
- 442
end page
- 454
volume
- 72