Barber, David S
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Barber, David S

Ast Prof

Positions

research areas research areas

selected publications

research overview

  • Exposure to chemicals in the environment can lead to adverse effects on the health of living organisms. These effects manifest themselves in a variety of ways, from subtle biochemical changes to overt disease and death. The overall goal of my research effort is to A) perform research that leads to development of novel strategies to mitigate the effects of environmental exposure and B) produce data that aids the establishment of appropriate environmental regulations. To accomplish this, my research program investigates the mechanisms by which environmental chemicals cause toxicity in three interrelated areas: neurotoxicology, metals toxicology, and aquatic toxicology. Recent projects have investigated the distribution and kinetics of depleted uranium in the brain and conducted studies to determine the neurological effects produced by exposure to uranium. Recently, my research on metals has expanded into the area of nanometallics and investigates whether metallic nanoparticles pose a risk to aquatic organisms that is unique from dissolved metals. A second area of research is identifying the mechanisms by which acrylamide and structurally related chemicals produce nerve terminal degeneration. This work focuses on the formation of protein cysteine adducts in nerve terminals as a critical target for neuropathy. A third area of research is determining the mechanisms by which organochlorine compounds (and other endocrine active compounds) affect steroid homeostasis in largemouth bass. This project focuses on the hypothalamic-pituitary-gonad (HPG) axis control of steroid synthesis. My laboratory uses a variety of in vivo and in vitro models, coupled with genomic, proteomic and other analytical techniques to investigate these questions.

principal investigator on

co-principal investigator on

teaching activities

full name

  • David S Barber
  • Dr David S Barber

primary email

  • barberd@ufl.edu

mailing address

phone

  • (352) 294-4636
Publications in VIVO
  • Contact Info
  • (352) 294-4636