abstract The combination of complete diaphragm inactivity and mechanical ventilation (for more than 18 hours) elicits disuse atrophy of myofibers in animals. We hypothesized that the same may also occur in the human diaphragm.
authors Levine, Sanford Kaiser, Larry R. Rubinstein, Neal A. Powers, Scotty K Shrager, Joseph B. Nguyen, Taitan Taylor, Nyali Friscia, Michael E. Budak, Murat T. Rothenberg, Pamela Zhu, Jianliang Sachdeva, Rajeev Sonnad, Seema
has subject area Adolescent Adult Aged Biopsy Brain Death Case-Control Studies Diaphragm Female Gene Expression Humans Male Middle Aged Muscle Fibers, Skeletal Muscle Proteins Muscular Atrophy Pectoralis Muscles RNA, Messenger Respiration, Artificial SKP Cullin F-Box Protein Ligases Tissue Donors Ubiquitin-Protein Ligases