Deletion of Methylglyoxal Synthase Gene (Mgsa) Increased Sugar Co-Metabolism in Ethanol-Producing Escherichia Coli Academic Article Conference Paper uri icon

abstract

  • The use of lignocellulose as a source of sugars for bioproducts requires the development of biocatalysts that maximize product yields by fermenting mixtures of hexose and pentose sugars to completion. In this study, we implicate mgsA encoding methylglyoxal synthase (and methylglyoxal) in the modulation of sugar metabolism. Deletion of this gene (strain LY168) resulted in the co-metabolism of glucose and xylose, and accelerated the metabolism of a 5-sugar mixture (mannose, glucose, arabinose, xylose and galactose) to ethanol.

publication date

  • 2009-09-01

PubMed Central ID

  • PMC2721133

Web of Science ID

  • 000268726500012

PubMed ID

  • 19458924

start page

  • 1389

end page

  • 1398

volume

  • 31